موضوع: رد: Questions and answers on endocrine and reproduction physiology (11-2012) by Dr Khaled A Abulfadle الجمعة نوفمبر 16, 2012 5:26 pm
Mechanism of numbness in diabetes
As You Know diabetes is a metabolic disorder due to qualitative or quantitative insulin difficiency that leads to many complications one of which is microvascular disorder that leads to sensory neuropathy which causes numbness.
Diabetic microvascular (involving small vessels, such as capillaries) and macrovascular (involving large vessels, such as arteries and veins) complications have similar etiologic characteristics.
Chronic hyperglycemia plays a major role in the initiation of diabetic vascular complications through many metabolic and structural derangements, including the production of advanced glycation end products (AGE), abnormal activation of signaling cascades (such as protein kinase C [PKC]), elevated production of reactive oxygen species (ROS, oxygen-containing molecules that can interact with other biomolecules and result in damage), and abnormal stimulation of hemodynamic regulation systems (such as the renin-angiotensin system [RAS]).
Questions and answers on endocrine and reproduction physiology (11-2012) by Dr Khaled A Abulfadle